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New research offers clues as to why dengue virus can still infect people who have been vaccinated, according to Nature. The findings could help explain breakthrough infections and inform work on more effective dengue vaccines. Dengue infects hundreds of millions of people each year, and vaccine protection has proven uneven across the four virus serotypes.
Researchers are taking seriously the idea of placing a giant sunshade in space to block some sunlight and cool the planet. The concept is a form of solar geoengineering that could theoretically address global warming but raises major feasibility, governance and environmental questions.
A meta-study raises questions about whether commonly used measures capture what it means to be good at regulating emotions. The findings could affect how psychologists assess emotional health and design interventions.
New findings show that genetic variants shape chromatin accessibility in specific cell types, linking cell-type-specific gene regulation to disease. This helps explain how noncoding risk variants act and improves interpretation of disease genetics.
Researchers have freshly cultivated archaea that provide new clues about how complex life may have evolved. The work could help clarify the biological transitions that led from simple microbes to eukaryotes. It matters because it sheds light on a central question in evolutionary biology.
Two Nature studies show that tandem repeat variation and both rare and common genetic variants influence gene expression in immune cells in a cell-type-specific manner. The findings help explain how genetic differences regulate immune cell function and may inform understanding of immune-related disease.
Researchers report a carbon ribbon made of pentagons and heptagons that shows metallic behavior, according to Nature. The finding expands the range of known carbon nanostructures and could inform the design of nanoscale electronic materials.
Researchers used simulations of the Drosophila connectome to identify a central pattern generator — a neural circuit that produces rhythmic walking movements in fruit flies. The work links detailed wiring diagrams to actual behavior, helping explain how nervous systems generate coordinated locomotion. It offers a template for using connectome data to uncover circuit mechanisms in other animals.
A Nature study reports that human cortical neurons carrying genetic abnormalities are removed during the perinatal period. The finding suggests quality-control mechanisms in the developing brain eliminate aberrant neurons around birth. It matters because it helps explain how the brain limits genetic damage and may inform neurodevelopmental disease research.