# Personalized mRNA vaccine cuts melanoma recurrence and death risk in trial

A clinical trial showed that a bespoke mRNA vaccine significantly reduced the risk of melanoma recurrence or death. The vaccine is tailored to individual tumor mutations and could become a new adjuvant treatment for high-risk melanoma if larger trials confirm the benefit. The result is a major step for personalized cancer vaccines.

**Importance:** 4/5

## Sources

### Health
- [The Guardian Health](https://www.theguardian.com/society/2026/oct/23/mrna-vaccine-melanoma-cancer-breakthrough-australia) — Fri, 23 Oct 2026 04:27:18 GMT
- [BBC Health](https://www.bbc.co.uk/news/articles/cq0ld9g9e913o?at_medium=RSS&at_campaign=rss) — Fri, 23 Oct 2026 07:49:02 GMT
- [NPR Health](https://www.npr.org/2026/10/26/nx-s1-6013568/mercks-melanoma-vaccine-trial-shows-reduced-recurrence-or-death-from-skin-cancer) — Mon, 26 Oct 2026 04:42:43 -0400