# Spatiotemporal cell trajectory explains glioblastoma heterogeneity

Researchers report in Nature that a spatiotemporal cancer cell trajectory underlies the heterogeneity of glioblastoma, a lethal brain cancer. The work maps how tumor cells may evolve across space and time, helping explain why tumors vary and resist treatment. It could inform future strategies targeting distinct cancer cell states.

**Importance:** 3/5

## Sources

### Science
- [Nature](https://www.nature.com/articles/s41586-026-11234-8) — 2026-11-04